Quercetagitrin

Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta) . Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM) . Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes[1][2][3][4].

Product Specifications

CAS Number

[548-75-4]

Product Name Alternative

Quercetagetin-7-O-glucoside

UNSPSC

12352005

Target

NF-κB; Phosphatase; Tau Protein

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/quercetagitrin.html

Concentration

10mM

Purity

98.34

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=C(O)C(O)=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC(O)=C(O)C=C4)=C1O

Molecular Formula

C21H20O13

Molecular Weight

480.38

References & Citations

[1]BY P. SURYAPRAKASA RAO, et al. Isolation and constitution of quercetagitrin, a glucoside of quercetagetin. Proceedings of the Indian Academy of Sciences - Section A. 1941.|[2]Tordera M, et al. Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils. Z Naturforsch C. 1994 Mar-Apr;49 (3-4) :235-40.|[3]Zhong, S., et al., (2023) . Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice. Molecules (Basel, Switzerland), 28 (9), 3964. |[4]Gone, G. B., et al., (2024) . Exploring the Anti-Diabetic Potential of Quercetagitrin through Dual Inhibition of PTPN6 and PTPN9. Nutrients, 16 (5), 647.