Promegestone

Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].

Product Specifications

CAS Number

[34184-77-5]

Product Name Alternative

R-5020; Surgestone

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/promegestone.html

Purity

99.14

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@](C)(CC[C@]1([C@@]3(CCC4=CC(CCC4=C3CC2)=O)[H])[H])C(CC)=O

Molecular Formula

C22H30O2

Molecular Weight

326.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Clémentine Garoche, et al. Human and Zebrafish Nuclear Progesterone Receptors Are Differently Activated by Manifold Progestins. Environ Sci Technol. 2020 Aug 4;54 (15) :9510-9518.|[2]Michael A Kirby, et al. Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition. Reprod Sci. 2016 Nov;23 (11) :1473-1483.|[3]Todd P Knutson, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017 Apr 17;10 (1) :89.