β-Endorphin, equine (TFA)

β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties[1][2][3][4].

Product Specifications

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/beta-endorphin-equine-tfa.html

Purity

97.10

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.OC(C=C1)=CC=C1C[C@H](N)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C154H248N42O44S.xC2HF3O2

Molecular Weight

3423.94 (free acid)

References & Citations

[1]Yahav Dikshtein, et al. β-Endorphin via the Delta Opioid Receptor is a Major Factor in the Incubation of Cocaine Craving. Neuropsychopharmacology. 2013 Nov; 38 (12) : 2508-2514.|[2]Niinistö KE, et al. Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic. Vet J. 2010 Apr;184 (1) :100-4.|[3]Izquierdo I. Effects of a low and a high dose of beta-endorphin on acquisition and retention in the rat. Behav Neural Biol. 1980 Dec;30 (4) :460-4.|[4]Loh HH, et al. beta-Endorphin in vitro inhibition of striatal dopamine release. Nature. 1976 Dec 9;264 (5586) :567-8.