Bemotrizinol

Bemotrizinol (Tinosorb S), a compound that can absorb ultraviolet light, has been shown to accept atomic oxygen generated by N-oxide photodeoxygenation[1][2][3][4].

Product Specifications

CAS Number

[187393-00-6]

Product Name Alternative

Tinosorb S

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bemotrizinol.html

Purity

98.0

Solubility

Chloroform : 50 mg/mL (ultrasonic)

Smiles

CCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)OC)C4=C(C=C(C=C4)OCC(CC)CCCC)O)O

Molecular Formula

C38H49N3O5

Molecular Weight

627.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Durán-Giner N, et al. Solar filters as feasible acceptors of atomic oxygen. Photochem Photobiol Sci. 2013;12 (5) :725-728.|[2]D'Ruiz CD, et al. Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph. Regul Toxicol Pharmacol. 2023 Mar;139:105344.|[3]Hashim D M, et al. Enhancing the sunscreen efficacy of bemotrizinol micropigment by using o/w nanoemulsion topical preparations[J]. Int J Pharm Pharm Sci, 2019, 11 (7) : 47-56.|[4]Yap FH, et al. Active sunscreen ingredients in Australia. Australas J Dermatol. 2017 Nov;58 (4) :e160-e170.|[5]Sarpietro M G, et al. Bemotrizinol-Loaded Nanostructured Lipid Carriers for the Development of Sunscreen Emulsions[J]. Journal of Microencapsulation, 2024.