PCSK9 Recombinant Rabbit Monoclonal Antibody [JE30-37]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1. It is the 9th member of the proprotein convertase family of proteins that activate other proteins. Similar genes (orthologs) are found across many species. As with many proteins, PCSK9 is inactive when first synthesized, because a section of peptide chains blocks their activity; proprotein convertases remove that section to activate the enzyme. The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PCSK9, NARC1, PSEC0052
Swiss Prot
Q8NBP7 Human
Cellular Locus
Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human PCSK9 aa 550-590/692.
Isotype
IgG
Clone
JE30-37
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IP
Positive Control
Huh7 cell lysate, BxPC-3 cell lysate, HeLa cell lysate, A431 cell lysate, human colon cancer tissue, human kidney tissue, human pancreas tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:200 ;IP: 1-2μg/sample
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 74 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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