LY2409881 (trihydrochloride)
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
Product Specifications
CAS Number
[946518-60-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; IKK
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY2409881-trihydrochloride.html
Concentration
10mM
Purity
98.33
Solubility
DMSO : 14.29 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C24H32Cl4N6OS
Molecular Weight
594.43
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β
Citation 01
Cell Rep. 2024 Oct 8;43 (10) :114827.|Clin Transl Med. 2022 Jun;12 (6) :e850.|Int J Mol Sci. 2022 Dec 24;24 (1) :320.
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