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LY2409881 (trihydrochloride)

Product Specifications

UNSPSC Description

LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.

Target Antigen

Apoptosis; IKK

Type

Reference compound

Related Pathways

Apoptosis;NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LY2409881-trihydrochloride.html

Purity

98.14

Solubility

DMSO : 14.29 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5.[H]Cl.[H]Cl.[H]Cl

Molecular Weight

594.43

References & Citations

[1]Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45.Cell Rep. 2024 Oct 8;43(10):114827.|Clin Transl Med. 2022 Jun;12(6):e850.|Int J Mol Sci. 2023, 24(1), 320.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B0788A/LY2409881-trihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B0788A/LY2409881-trihydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

946518-60-1

Available Sizes

Curated Selection

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