LY2409881 (trihydrochloride)

LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.

Product Specifications

CAS Number

[946518-60-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; IKK

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LY2409881-trihydrochloride.html

Concentration

10mM

Purity

98.33

Solubility

DMSO : 14.29 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C24H32Cl4N6OS

Molecular Weight

594.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21 (1) :134-45.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IKK-β

Citation 01

Cell Rep. 2024 Oct 8;43 (10) :114827.|Clin Transl Med. 2022 Jun;12 (6) :e850.|Int J Mol Sci. 2022 Dec 24;24 (1) :320.

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