NZ 419
NZ 419 (5-Hydroxy-1-methylhydantoin) is a metabolite of creatinine and an antioxidant with oral activity, which has the ability to scavenge hydroxyl radicals (•OH) . NZ 419 can inhibit the progression of chronic kidney disease (CKD) in rats[1].
Product Specifications
CAS Number
[84210-26-4]
Product Name Alternative
5-Hydroxy-1-methylhydantoin
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nz-419.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(O)N1C)=O
Molecular Formula
C4H6N2O3
Molecular Weight
130.10
Precautions
H315, H319
References & Citations
[1]Ienaga K, et al. Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers. Drug Discov Ther. 2011;5 (4) :162-175.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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