Helenalin

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding[1][2].

Product Specifications

CAS Number

[6754-13-8]

UNSPSC

12352005

Hazard Statement

H301

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/helenalin.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@]2([H])C(C(O[C@@]2(C[C@H]([C@@]([H])([C@]13C)C=CC3=O)C)[H])=O)=C

Molecular Formula

C15H18O4

Molecular Weight

262.31

Precautions

H301

References & Citations

[1]Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23 (2) :159-69.|[2]Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273 (50) :33508-16.|[3]Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21 (Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105 (3) :913-21.