Semax

Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10) . Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].

Product Specifications

CAS Number

[80714-61-0]

UNSPSC

12352209

Hazard Statement

H315, H319, H335

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/semax.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC=N2)NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)=O)N3CCC[C@H]3C(NCC(N4CCC[C@H]4C(O)=O)=O)=O

Molecular Formula

C37H51N9O10S

Molecular Weight

813.92

Precautions

H315, H319, H335

References & Citations

[1]Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. |[2]Sciacca MFM, et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13 (4) :486-496. |[3]Grivennikov IA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restor Neurol Neurosci. 2008;26 (1) :35-43. |[4]Shadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308 (2) :115-8. |[5]Eremin KO, et al. Semax, an ACTH (4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30 (12) :1493-500.