YS-67

YS-67 is a potent inhibitor of EGFR with an IC 50 of 5.2 nM. YS-67 significantly inhibits p-EGFR and p-AKT. YS-67 inhibits the proliferation of A549, PC-9, and A431cells with IC 50s of 4.1, 0.5, and 2.1 μM, respectively[1].

Product Specifications

CAS Number

[2761327-15-3]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ys-67.html

Purity

99.41

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(OCCCN2CCOCC2)C=C3C(C(C4=CC=CC=C4N5CC)=C5C6=CC=CC=C6)=NC=NC3=C1

Molecular Formula

C32H34N4O3

Molecular Weight

522.64

References & Citations

[1]He P, et al. Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors. Bioorg Chem. 2024 Jan;142:106970.