YS-67
YS-67 is a potent inhibitor of EGFR with an IC 50 of 5.2 nM. YS-67 significantly inhibits p-EGFR and p-AKT. YS-67 inhibits the proliferation of A549, PC-9, and A431cells with IC 50s of 4.1, 0.5, and 2.1 μM, respectively[1].
Product Specifications
CAS Number
[2761327-15-3]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ys-67.html
Purity
99.41
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(OCCCN2CCOCC2)C=C3C(C(C4=CC=CC=C4N5CC)=C5C6=CC=CC=C6)=NC=NC3=C1
Molecular Formula
C32H34N4O3
Molecular Weight
522.64
References & Citations
[1]He P, et al. Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors. Bioorg Chem. 2024 Jan;142:106970.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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