TNAP-IN-1
TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC50 of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification[1].
Product Specifications
CAS Number
[496014-13-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnap-in-1.html
Purity
98.56
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(NC1=CN=C2C=CC=CC2=C1)(C3=CC(OC)=CC=C3OC)=O
Molecular Formula
C17H16N2O4S
Molecular Weight
344.38
Precautions
H315, H319, H320
References & Citations
[1]Dahl R, et al. Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) . J Med Chem. 2009 Nov 12;52 (21) :6919-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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