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Dynole 2−24

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I) . Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀ (CME) =1.9 μM) . Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

Product Specifications

CAS Number

1416313-72-8

UNSPSC

12352005

Target

Dynamin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dynole-2-24.html

Purity

99.07

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CN(C)CCCN1C=C(CNCCCCCCCCCC)C2=C1C=CC=C2

Molecular Formula

C24H41N3

Molecular Weight

371.60

References & Citations

[1]Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56 (1) :46-59.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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