Monomethyl auristatin E intermediate-15

Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162) . Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[173653-47-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-15.html

Purity

95.04

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@H](C)C(OCC1=CC=CC=C1)=O)[C@H]2N(C(OC(C)(C)C)=O)CCC2

Molecular Formula

C20H29NO5

Molecular Weight

363.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.