(S) -LY-3381916

(S) -LY-3381916 ((S) -IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S) -LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ[1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[2].

Product Specifications

CAS Number

[2166616-76-6]

Product Name Alternative

(S) -IDO1-IN-5

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-ly-3381916.html

Purity

99.06

Solubility

DMSO : 300 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C1=CC2=C(N(C(C3CCOCC3)=O)CC2)C=C1)C)C4=CC=C(F)C=C4

Molecular Formula

C23H25FN2O3

Molecular Weight

396.45

References & Citations

[1]Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78 (13) .|[2]Jolie Anne Bastian, et al. 1-tetrahydropyranylcarbonyl-2,3-dihydro-1h-indole compounds for treating cancer. WO2017213919A1.