Oxybuprocaine

Oxybuprocaine is a short-acting ester anesthetic. Oxybuprocaine binds to sodium channels and reversibly stabilizes neuronal membranes. Oxybuprocaine has cutaneous analgesic properties. Oxybuprocaine is less potent than Bupivacaine (HY-B0405) at producing central nervous system and cardiovascular toxicity. Oxybuprocaine can be used in ophthalmology and otolaryngology[1][2][3][4][5][6].

Product Specifications

CAS Number

[99-43-4]

Product Name Alternative

Benoxinate; Novesinol; Oxybucaine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/oxybuprocaine.html

Purity

99.93

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(OCCN(CC)CC)C1=CC=C(N)C(OCCCC)=C1

Molecular Formula

C17H28N2O3

Molecular Weight

308.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Masayuki Kohsaka, et al. Oxybuprocaine for apraxia of lid opening in Parkinson's disease: A placebo-controlled pilot trial. Mov Disord|[2]Nam SM, et al. Comparison of corneal thickness after the instillation of topical anesthetics: proparacaine versus oxybuprocaine. Cornea. 2006 Jan;25 (1) :51-4. |[3]Tomaciello F, et al. Resveratrol lacks protective activity against acute seizures in mouse models. Neurosci Lett. 2016 Oct 6;632:199-203.|[4]Hung CH, et al. The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats. Anesth Analg. 2010 Jan 1;110 (1) :238-42. |[5]Mirković I, et al. Pentadecapeptide BPC 157 shortens duration of tetracaine-and oxybuprocaine-induced corneal anesthesia in rats. Acta Clinica Croatica, 2020, 59 (3) : 394. |[6]Dong Z, et al. Efficacy and Safety of Oxybuprocaine Hydrochloride Gel in Alleviating Pain during Male Urethral Catheterization: A Single-Center Randomized Controlled Study. Int J Clin Pract. 2022 Sep 14;2022:5734387.