JAB-3068 (hydrochloride)
JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7[1].
Product Specifications
CAS Number
[2169223-49-6]
Product Name Alternative
SHP2-IN-6 (hydrochloride)
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jab-3068-hydrochloride.html
Purity
98.88
Solubility
DMSO : 115 mg/mL (ultrasonic)
Smiles
CC(N1CC(F)(F)C2=C1C=CC=C2SC3=NC=C(N(CC4)CCC54[C@H](N)COC5)N=C3N)=O.[H]Cl
Molecular Formula
C22H27ClF2N6O2S
Molecular Weight
513.00
References & Citations
[1]Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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