6-Hydroxynicotinic acid

6-Hydroxynicotinic acid is an intermediate in the oxidation of Nicotinic acid (HY-B0143) by Pseudomonas fluorescens and metabolite. 6-Hydroxynicotinic acid can be isolated from root exudates of Cucumis melo. 6-Hydroxynicotinic acid disrupts the Auxin signaling pathway. 6-Hydroxynicotinic acid inhibits haustoria precursor formation in Phlipanche aegyptiaca[1][2].

Product Specifications

CAS Number

[5006-66-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Drug Intermediate; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/6-hydroxynicotinic-acid.html

Purity

99.93

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(O)N=C1

Molecular Formula

C6H5NO3

Molecular Weight

139.11

Precautions

H315, H319, H335

References & Citations

[1]Hu X, et al. 6-Hydroxynicotinic Acid From Cucumis melo Inhibits Prehaustorium Formation in Phelipanche aegyptiaca via Disruption of Auxin Signalling Pathway. Mol Plant Pathol. 2025 Aug;26 (8) :e70137. |[2]HUGHES DE. 6-Hydroxynicotinic acid as an intermediate in the oxidation of nicotinic acid by Pseudomonas fluorescens. Biochem J. 1955 Jun;60 (2) :303-10.