PROTAC SOS1 degrader-7
PROTAC SOS1 degrader-7 (Example 15) is a SOS1 PROTAC degrader. PROTAC SOS1 degrader-7 has anti-tumor activity. (Pink: SOS1 ligand ; Black: linker (HY-163584) ; Blue: E3 ligase ligand (HY-W454906) ).
Product Specifications
CAS Number
3036155-26-4
UNSPSC
12352005
Target
PROTACs; Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-sos1-degrader-7.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C(C2=C1C=NC(N3CCN(CC3)C(C4CCN(CC4)CC5CCC6(CCN(CC6)C(C7=CC(N8CCC(NC8=O)=O)=C(C=C7)C)=O)CC5)=O)=C2)N[C@@H](C9=CC=CC(C(F)F)=C9C)C
Molecular Formula
C51H64F2N10O4
Molecular Weight
919.12
References & Citations
[1]Zhengqing Ye, et al. Sos1 protein degradation agent and use thereof. WO2024083257A1.2024-04-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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