β-Aminopropionitrile (hydrochloride)

β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2].

Product Specifications

CAS Number

[646-03-7]

Product Name Alternative

BAPN (hydrochloride)

UNSPSC

12352211

Hazard Statement

H301

Target

Endogenous Metabolite; Monoamine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/β-aminopropionitrile-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

NCCC#N.Cl

Molecular Formula

C3H7ClN2

Molecular Weight

106.55

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8 (6) :543-51.|[2]Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29 (2) :541-8.|[3]Ren W, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep. 2016 Jun 22;6:28149.