PDE4-IN-15
PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC50 = 0.17 μM) and has anti-TNF-α activity (EC50 = 0.19 μM) . PDE4-IN-15 has a good skin permeability[1].
Product Specifications
CAS Number
3034837-89-0
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-15.html
Solubility
10 mM in DMSO
Smiles
OC[C@H]1C2=C(O[C@@H]1C3=CC(OCC)=C(C=C3)OC)C(OCC)=CC(CCCO)=C2
Molecular Formula
C23H30O6
Molecular Weight
402.48
References & Citations
[1]Chenming Gu, et al. Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model. J Med Chem. 2024, 67, 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Frequently Asked Questions
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