Illudin S

Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells[1][2][3][4].

Product Specifications

CAS Number

[1149-99-1]

UNSPSC

12352211

Target

Apoptosis; DNA Alkylator/Crosslinker

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/illudin-s.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=C[C@](C)([C@@H](C2=C(C3([C@@]1(C)O)CC3)C)O)CO

Molecular Formula

C15H20O4

Molecular Weight

264.32

References & Citations

[1]Hansruedi Glatt, et al. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol . 2014 Jan;88 (1) :161-9.|[2]Nicolaas G J Jaspers, et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst) . 2002 Dec 5;1 (12) :1027-38.|[3]Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens|[4]M J Kelner, et al. Preclinical evaluation of illudins as anticancer agents. Cancer Res. 1987 Jun 15;47 (12) :3186-9.