Kurarinone

Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

[34981-26-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Eukaryotic Initiation Factor (eIF)

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kurarinone.html

Purity

99.47

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(OC)=C13

Molecular Formula

C26H30O6

Molecular Weight

438.51

Precautions

H315, H319

References & Citations

[1]Xie L, et al. The flavonoid kurarinone inhibits clinical progression of EAE through inhibiting Th1 and Th17 cell differentiation and proliferation. Int Immunopharmacol. 2018 Sep;62:227-236.|[2]Nishikawa S, et al. Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. Molecules. 2019 Aug 27;24 (17) :3110.|[3]Tang KT, et al. Kurarinone Attenuates Collagen-Induced Arthritis in Mice by Inhibiting Th1/Th17 Cell Responses and Oxidative Stress. Int J Mol Sci. 2021 Apr 13;22 (8) :4002.