MKK7-COV-9
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein-protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM[1].
Product Specifications
CAS Number
[2283355-59-7]
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mkk7-cov-9.html
Purity
97.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC)C1=CC(NC(C=C)=O)=CC(C2=NNC3=C2C=CC=C3)=C1
Molecular Formula
C18H16N4O2
Molecular Weight
320.35
References & Citations
[1]Amit Shraga, et al. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chem Biol. 2019 Jan 17;26 (1) :98-108.e5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38 MAPK
Available Sizes
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