Z-335 (sodium)

Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively[1][2].

Product Specifications

CAS Number

[146731-14-8]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/z-335-sodium.html

Smiles

O=C(CC1=CC=C2C(CC(C2)CNS(=O)(C3=CC=C(C=C3)Cl)=O)=C1)O[Na]

Molecular Formula

C18H17ClNNaO4S

Molecular Weight

401.84

References & Citations

[1]T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357 (1) :53-60.|[2]T Tanaka, et al. Z-335, a new thromboxane A (2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401 (3) :413-8.