ND-011992

ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].

Product Specifications

CAS Number

[2446880-46-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Bacterial; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nd-011992.html

Purity

98.26

Solubility

DMSO : 40 mg/mL (ultrasonic; adjust pH to 4 with 1 M HCl)

Smiles

FC(F)(F)C(C=C1)=CC=C1OC(C=C2)=CC=C2NC3=NC=NC4=CC=CC=C43

Molecular Formula

C21H14F3N3O

Molecular Weight

381.35

Precautions

H302, H315, H319

References & Citations

[1]Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13 (1) :12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w