HSD17B13-IN-3

HSD17B13-IN-3 (compound 2) is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor with IC50s of 0.38 μM and 0.45 μM in biochemical assays using both β-estradiol or Leukotriene B4 (LTB4) as substrate and NAD+ as cofactor. HSD17B13-IN-3 shows low cell penetration[1].

Product Specifications

CAS Number

[313259-88-0]

UNSPSC

12352005

Target

17β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsd17b13-in-3.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 260 mg/mL (ultrasonic)

Smiles

CC1=C(S(C2=CC=C(C)C=C2)(=O)=O)C=C(C)C=C1S(=O)(NC3=CC=C(C(O)=O)C=C3)=O

Molecular Formula

C22H21NO6S2

Molecular Weight

459.54

References & Citations

[1]Liu S, et, al. Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun. 2023 Aug 24;14 (1) :5158.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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