SSTC3
Product Specifications
UNSPSC Description
SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors[1].
Target Antigen
Casein Kinase; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sstc3.html
Purity
98.65
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C2=NC=CC=C2)=CS1)C3=CC=C(S(=O)(N(C)C4=CC=C(C(F)(F)F)C=C4)=O)C=C3
Molecular Weight
518.53
References & Citations
[1]Li B, et al, Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120675/SSTC3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120675/SSTC3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1242422-09-8
Available Sizes
Curated Selection
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