SSTC3

SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM) . SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors[1].

Product Specifications

CAS Number

[1242422-09-8]

UNSPSC

12352005

Target

Casein Kinase; Wnt

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sstc3.html

Concentration

10mM

Purity

99.37

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC(C2=NC=CC=C2)=CS1)C3=CC=C(S(=O)(N(C)C4=CC=C(C(F)(F)F)C=C4)=O)C=C3

Molecular Formula

C23H17F3N4O3S2

Molecular Weight

518.53

References & Citations

[1]Li B, et al, Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10 (485) . pii: eaak9916.