Entrectinib (Standard)
Entrectinib (Standard) is the analytical standard of Entrectinib. This product is intended for research and analytical applications. Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice[1][2][3].
Product Specifications
CAS Number
[1108743-60-7]
Product Name Alternative
NMS-E628 (Standard) ; RXDX-101 (Standard)
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Autophagy; Reference Standards; ROS Kinase; Trk Receptor
Type
Reference Standards
Related Pathways
Autophagy; Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/entrectinib-standard.html
Smiles
O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6CCN(C)CC6)C=C4
Molecular Formula
C31H34F2N6O2
Molecular Weight
560.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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