GSK583
GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.
Product Specifications
CAS Number
[1346547-00-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/GSK583.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1
Molecular Formula
C20H19FN4O2S
Molecular Weight
398.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Haile PA et al. The Identification and Pharmacological Characterization of 6- (tert-Butylsulfonyl) -N- (5-fluoro-1H-indazol-3-yl) quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem, 2016 May 26, 59 (10) :4867-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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