GSK583

GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.

Product Specifications

CAS Number

[1346547-00-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/GSK583.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1

Molecular Formula

C20H19FN4O2S

Molecular Weight

398.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Haile PA et al. The Identification and Pharmacological Characterization of 6- (tert-Butylsulfonyl) -N- (5-fluoro-1H-indazol-3-yl) quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem, 2016 May 26, 59 (10) :4867-80.