Phospho-PKCa (Thr497) Rabbit FITC Conjugate

<strong>Phospho-PKCa (Thr497) Rabbit FITC Conjugate</strong>_x000D_ <strong>Catalog number:</strong> B2018542_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Protein kinase C alpha type, PKC-alpha, PRKCA, PKCA, PRKACA_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Gysin S, Imber R. Phorbol-ester-activated protein kinase C-alpha lacking phosphorylation at Ser657 is down-regulated by a mechanism involving dephosphorylation Eur J Biochem. 1997 Oct 1;249(1):156-60._x000D_ 2: Stempka L, Schnölzer M, Radke S, Rincke G, Marks F, Gschwendt M. Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643 J Biol Chem. 1999 Mar 26;274(13):8886-92._x000D_ 3: Cazaubon S, Bornancin F, Parker PJ. Threonine-497 is a critical site for permissive activation of protein kinase C alpha Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):443-8._x000D_ 4: Cazaubon SM, Parker PJ. Identification of the phosphorylated region responsible for the permissive activation of protein kinase C J Biol Chem. 1993 Aug 15;268(23):17559-63._x000D_ 5: Kuo KL, Zhao JF, Huang PH, Guo BC, Tarng DC, Lee TS. Indoxyl sulfate impairs valsartan-induced neovascularization Redox Biol. 2020 Feb;30:101433._x000D_ 6: He A, Zuo D, Liang X, Guo Y, Suxin L, Xia Y. Hypoglycemia increases endothelial-dependent vasodilation through suppressing phosphorylation at Threonine 495/497 site of endothelial nitric oxide synthase Microvasc Res. 2021 Jan;133:104075._x000D_ 7: Hu S, Pi Q, Xu X, Yan J, Guo Y, Tan W, He A, Cheng Z, Luo S, Xia Y. Disrupted eNOS activity and expression account for vasodilator dysfunction in different stage of sepsis Life Sci. 2021 Jan 1;264:118606._x000D_ 8: Partovian C, Zhuang Z, Moodie K, Lin M, Ouchi N, Sessa WC, Walsh K, Simons M. PKCalpha activates eNOS and increases arterial blood flow in vivo Circ Res. 2005 Sep 2;97(5):482-7._x000D_ 9: Oh CD, Kim SJ, Ju JW, Song WK, Kim JH, Yoo YJ, Chun JS. Immunosuppressant rapamycin inhibits protein kinase C alpha and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis Eur J Pharmacol. 2001 Sep 21;427(3):175-85._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/15616014">10: Devaraj S, Venugopal SK, Singh U, Jialal I. Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta} Diabetes. 2005 Jan;54(1):85-91. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-PKCa (Thr497) Rabbit FITC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>