NS309

NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels[1][2][3][4].

Product Specifications

CAS Number

[18711-16-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/NS309.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=CC(Cl)=C2Cl)/C1=N/O

Molecular Formula

C8H4Cl2N2O2

Molecular Weight

231.04

Precautions

H315, H319, H335

References & Citations

[1]Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I (AHP) and modulates the firing properties of hippocampal pyramidal neurons.|[2]C Hougaard, et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul; 151 (5) : 655–665.|[3]Nichole Coleman, et al. New Positive Ca2+-Activated K+ Channel Gating Modulators with Selectivity for KCa3.1. Mol Pharmacol. 2014 Sep; 86 (3) : 342–357.|[4]Dorte Strøbaek, et al. Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) . Biochim Biophys Acta. 2004 Oct 11;1665 (1-2) :1-5.|[5]Shankar P Parajuli, et al. NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels. Br J Pharmacol. 2013 Apr; 168 (7) : 1611–1625.|[6]Jie Zhu, et al. Activation of SK/KCa Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits. Front Pharmacol. 2019; 10: 325.