6-Phosphogluconic acid (trisodium)

6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].

Product Specifications

CAS Number

[53411-70-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335, H371

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6-phosphogluconic-acid-trisodium.html

Purity

99.84

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C(O[Na])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O[Na])(O[Na])=O

Molecular Formula

C6H10Na3O10P

Molecular Weight

342.08

Precautions

H302, H315, H319, H335, H371

References & Citations

[1]Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52 (5) :1348-52.|[2]Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22 (5) :585-600.