Pomalidomide-C7-NH2

Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) (Compound 24g) is an E3 Ligase Ligand-Linker Conjugates consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-C7-NH2 can be used for synthesis of PROTACs[1].

Product Specifications

CAS Number

[2093387-55-2]

Product Name Alternative

Pomalidomide 4'-alkylC7-amine

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-c7-nh2.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCCCCCCN)=CC=C3)=O)=O

Molecular Formula

C20H26N4O4

Molecular Weight

386.44

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62 (2) :448-466.