Cynomolgus Integrin alpha 6 beta 4 (ITGA6&ITGB4) Heterodimer Protein, His Tag&Tag Free (MALS verified)

Integrin α6β4 is a key laminin receptor predominantly found in stratified squamous epithelia, especially localized to hemidesmosomes in the basal epidermal layer, where it plays a crucial role in cell-basement membrane adhesion, regulation of keratinocyte motility and polarity, and contributes to the structure of hemidesmosomal plaques, distinguishing it from other integrins.

Product Specifications

Background

Specifications

Cynomolgus ITGA6&ITGB4 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA6 and ITGB4, has a calculated MW of 116.8 kDa (ITGA6) & 82 kDa (ITGB4) . Subunit ITGA6 is fused with flag tag at the C-terminus and subunit ITGB4 contains no tag. The protein migrates as 110-130 kDa (ITGA6) and 90-95 kDa (ITGB4) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Phe 24 - Gly 1012 (ITGA6) & Asn 28 - Ser 711 (ITGB4)

Target

Integrin alpha 6 beta 4

Conjugation

Unconjugated

Tag

C-10xHis | Native

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.