DL-Buthionine-(S,R)-sulfoximine
Product Specifications
UNSPSC Description
DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/D,L-Buthionine-_S,R_-sulfoximine.html
Purity
99.67
Solubility
H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
OC(C(N)CCS(CCCC)(=N)=O)=O
Molecular Weight
222.31
References & Citations
[1]Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60.|[2]Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106376/DL-Buthionine-S-R-sulfoximine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106376/DL-Buthionine-S-R-sulfoximine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
5072-26-4
Available Sizes
Curated Selection
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