AZD4619
AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug[1][2].
Product Specifications
CAS Number
549494-39-5
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/azd4619.html
Smiles
OC(C=C1)=CC=C1CCS[C@H](C(O)=O)CC2=CC=C(C=C2)CCOC3=CC=C(C=C3)OS(C)(=O)=O
Molecular Formula
C26H28O7S2
Molecular Weight
516.63
References & Citations
[1]Petra Thulin, et al. PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicol Appl Pharmacol. 2008 Aug 15;231 (1) :1-9. |[2]Petra Thulin, et al. The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels. Int J Mol Med. 2016 Sep;38 (3) :961-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα
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