WISP-1
WISP-1 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is expressed in the heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. WISP-1 is a beta catenin regulated protein that can contribute to tumorigenesis and has also been shown to play a role in bone development and fracture repair. Human WISP-1 is a 38.1 kDa protein containing 346 amino acid residues. It is composed of four distinct structural domains (modules) ; the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cystine knot-like (CTCK) domain.
Product Specifications
Synonyms
WISP1; CCN4; WISP1c; WISP1i; WISP1tc
NCBI Gene ID
8840
UniProt
O95388
Accession Number
NP_003873
Accession Number mRNA
NM_003882
Chromosomal Location
8q24.22
Reactivity
Human
Cross Reactivity
Mouse, Rat
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analysis
Bioactivity
The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
Length
346
Form
Lyophilized
Molecular Weight
38.1 kDa
Host or Source
E. coli
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