VCAM-1
VCAM is a 110 kDa, cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development of several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant Murine VCAM-1 is a 74.4 kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 87-97 kDa by SDS-PAGE analysis under reducing conditions.
Product Specifications
Synonyms
Vascular Cell Adhesion Molecule 1; CD106; INCAM-100; MGC108734; MGC99561; VCAM; VCAM1; VCAM1B; VECAM1
NCBI Gene ID
22329
UniProt
P29533
Accession Number
NP_035823.3
Accession Number mRNA
NM_011693.3
Chromosomal Location
3 G1; 3 50.17 cM
Reactivity
Mouse
Cross Reactivity
Human
Sequence
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to support the adhesion of human U937 cells.
Length
674
Form
Lyophilized
Molecular Weight
87-97 dDa reducing conditions
Host or Source
CHO cells
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