TRAIL R-1/DR4, soluble
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Product Specifications
Synonyms
TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1
NCBI Gene ID
8797
UniProt
O00220
Accession Number
NP_003835.3
Accession Number mRNA
NM_003844.3
Chromosomal Location
8p21
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 µg/ml.
Length
215
Form
Lyophilized
Molecular Weight
22.7 kDa
Host or Source
E. coli
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