TPO (Animal Free)
TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. The human TPO gene encodes for a 353 amino acid glycoprotein, which contains a 21 amino acid signal sequence, a 15 amino acid erythropoietin-like domain, and a highly glycosylated 179 amino acid C-terminal domain. Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Product Specifications
Synonyms
Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
NCBI Gene ID
7066
UniProt
P40225
Accession Number
NP_000451.1
Accession Number mRNA
NM_000460.2
Chromosomal Location
2p25
Reactivity
Human
Cross Reactivity
Human, Human + Hamster, Monkey, Mouse, Rat
Sequence
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Length
174
Form
Lyophilized
Molecular Weight
18.6 kDa
Host or Source
E. coli
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