TPO
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Product Specifications
Synonyms
Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
NCBI Gene ID
7066
UniProt
P40225
Accession Number
NP_000451.1
Accession Number mRNA
NM_000460.2
Chromosomal Location
2p25
Reactivity
Human
Cross Reactivity
Human
Sequence
Purity
> 98% by SDS-PAGE
Bioactivity
The ED50 as determined by the dose-dependant stimulation of MO7e cells is < 1 ng/ml (1x106 units/mg) .
Length
174
Form
Lyophilized
Molecular Weight
18.6 kDa
Host or Source
E. coli
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