TNFSF12 Protein (rFc Tag)
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.
Product Specifications
Synonyms
Apo3l Protein; Dr3l Protein; Dr3lg Protein; Tnfsf12 Protein; Tweak Protein
Accession Number
NP_035744.1
Reactivity
Mouse
Cross Reactivity
Mouse
Label
RFc-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 90 % as determined by SDS-PAGE
Bioactivity
Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC) . The ED50 for this effect is typically 10-50 ng/mL.
Length
396
Form
Lyophilized
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
44 kDa
Storage Conditions
Host or Source
HEK 293 cells
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