TNFSF12 Protein (hFc Tag)
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.
Product Specifications
Synonyms
Apo3l Protein; Dr3l Protein; Dr3lg Protein; Tnfsf12 Protein; Tweak Protein
Accession Number
NP_035744.1
Reactivity
Mouse
Cross Reactivity
Mouse
Label
HFc-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 90 % as determined by SDS-PAGE
Bioactivity
Data not available
Length
405
Form
Lyophilized
Buffer
20mM MES, 150mM Nacl, 10% Glycerol, 0.02% Tween20, 10% Trehalose, pH 6.0.
Reconstitution
See Datasheet
Molecular Weight
44 kDa
Storage Conditions
Host or Source
HEK 293 cells
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