TIMP-2
TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8 kDa protein containing 194 amino acid residues.
Product Specifications
Synonyms
Tissue inhibitor of metalloproteinases 2, CSC-21K
NCBI Gene ID
7077
UniProt
P16035
Accession Number
NP_003246
Accession Number mRNA
NM_003255
Chromosomal Location
17q25
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Length
194
Form
Lyophilized
Molecular Weight
21.8 kDa
Host or Source
E. coli
Frequently Asked Questions
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