TIGAR
TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Recombinant human TIGAR expressed in E. coli is a 29.9 kDa protein containing 269 amino-acid residues.
Product Specifications
Synonyms
TP53-induced glyclysis and apoptosis regulator
NCBI Gene ID
57103
UniProt
Q9NQ88
Accession Number
NP_065108
Accession Number mRNA
NM_020375
Chromosomal Location
12p13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
269
Form
Lyophilized
Molecular Weight
29.9 kDa
Host or Source
E. coli
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