TGF-beta 3 / TGFB3 Protein (hFc Tag)
Transforming growth factor (TGF) beta 3 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. TGF-beta 3 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell et al.) . TGF-beta 3 enhances glycosaminoglycan production by mesenchymal stromal cells, stimulates scar-free healing, and improves glucose tolerance and phenotypic changes in adipocyte morphology (Hall et al.; Holton et al.) . TGF-beta 3 induces proliferation of posterofrontal suture-derived mesenchymal stromal cells, and stimulates expression of fibroblast growth factors 2 and 18 (James et al.) .
Product Specifications
Synonyms
ARVD Protein; ARVD1 Protein; LDS5 Protein; RNHF Protein; TGF-beta3 Protein
Accession Number
P10600-1
Reactivity
Human
Cross Reactivity
Human
Label
HFc-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 90 % as determined by SDS-PAGE.
Bioactivity
Data not available
Length
373
Form
Lyophilized
Buffer
20 mM HEPES, 150 mM NaCl, 0.2% CHAPS, pH 7.0.
Reconstitution
See Datasheet
Molecular Weight
42 kDa
Storage Conditions
Host or Source
HEK 293 cells
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